Glutaminase Inhibitor II, BPTES
BPTES
CAS: 314045-39-1
Molecular Formula: C24H24N6O2S3
Glutaminase Inhibitor II, BPTES - Names and Identifiers
| Name | BPTES |
| Synonyms | BPTES CS-1542 Glutaminase Inhibitor II Glutaminase Inhibitor II, BPTES bis-2-(5-phenylaQtMido-1,2,4-Thiadiazol-2-yl)Ethylsulfide bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide |
| CAS | 314045-39-1 |
Glutaminase Inhibitor II, BPTES - Physico-chemical Properties
| Molecular Formula | C24H24N6O2S3 |
| Molar Mass | 524.68 |
| Density | 1.420±0.06 g/cm3(Predicted) |
| Solubility | DMSO: 52 mg/mL (Need ultrasonic and warming) |
| Appearance | powder |
| Color | white to beige |
| pKa | 9.13±0.50(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| In vitro study | BPTES inhibited glutaminase with an IC50 of 0.18 μm in human kidney cells and glutamate by microglia with an IC50 of 80-120 nM. In D54 cells containing mutant IDH1, BPTES preferentially slowed their cell growth. BPTES also inhibited glutaminase activity, decreased glutamate and α-kg levels, and increased glycolytic intermediates. BPTES (10 μm) inhibited the growth of mHCC 3-4 cells derived from LAP/MYC tumors. BPTES also inhibits the growth of MYC-dependent P493 cells by blocking DNA replication, causing cell death and lysis. |
| In vivo study | In LAP/MYC mice, BPTES (12.5 mg/kg, I. p.) prolonged survival without significant effects on MYC,GLS, or GLS2 levels. In mice bearing P493 tumor xenografts, BPTES (200 μg/mouse, I. p.) also inhibited tumor cell growth. |
Glutaminase Inhibitor II, BPTES - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
Glutaminase Inhibitor II, BPTES - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.906 ml | 9.53 ml | 19.059 ml |
| 5 mM | 0.381 ml | 1.906 ml | 3.812 ml |
| 10 mM | 0.191 ml | 0.953 ml | 1.906 ml |
| 5 mM | 0.038 ml | 0.191 ml | 0.381 ml |
Last Update：2024-01-02 23:10:35
Glutaminase Inhibitor II, BPTES - Reference Information
| biological activity | BPTES is a potent and selective glutamine GLS1 (KGA) inhibitor with an IC50 of 0.16 μm. It has no effect on the activity of glutamate dehydrogenase, and has only a weak inhibitory effect on the activity of gamma glutamyl transpeptidase. |
| Target | Value |
| Glutaminase GLS1 (KGA) | 0.16 μM |
Last Update：2024-04-09 19:05:17
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Spot supply
Product Name: BPTES Visit Supplier Webpage Request for quotationCAS: 314045-39-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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